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Author

H. Husebye

2 papers indexed here

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Open access Oct 2026

Human macrophages activate a coordinated program linking inflammation and cell death in response to intracellular Poly(I:C)

Macrophages sense viral double-stranded RNA (dsRNA) via the innate immune receptors TLR3 and MDA5 whose activation drives a robust inflammatory program, often coupled to cell death. TLR3/TRIF-dependent apoptosis has been described in response to dsRNA. Growing evidence suggests that dsRNA may trigger multiple forms...

Luigi Fiore, Lara Di Leonardo, M. Buscetta et al. · 0 citations
Open access Aug 2026

Cell-intrinsic complement C3 suppresses IFN-β production in macrophages

Findings identify cell-intrinsic C3 as a suppressor of IFN-β production in human macrophages, highlighting the importance of the cell-intrinsic complement system in fine-tuning inflammatory responses to pathogens.

Stine Kristensen, Charlotte Årseth, Maria Yurchenko et al. · 0 citations

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