H. Hiza

Host–strain compatibility shapes host transcriptional responses in macrophage in vitro infection models of Mycobacterium tuberculosis

Abstract Differences in host distribution are observed across Mycobacterium tuberculosis complex (MTBC) lineages, but investigating the molecular basis of host compatibility in vivo is challenging. Here, we establish an epidemiology-guided in vitro framework to operationalize ‘host compatibility’ as a theoretical param...