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H. H. Y. Tong

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Open access Aug 2026

The SIMDA framework maps PIP2-binding sites regulating the KCNQ1 channel

Voltage-gated potassium channel KCNQ1 (Kv7.1) underpins cardiac repolarization, epithelial ion transport, and inner ear function. Its versatility arises from interactions with KCNE proteins, calmodulin (CaM), and the lipid phosphatidylinositol 4,5-bisphosphate (PIP2), yet the molecular basis of PIP2 regulation remains...

Ling-Ling Wang, Shu Li, Yun-Sen Zhang et al. · 0 citations

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