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Open access Sep 2026

Association between CAR T-cell persistence and improved response to salvage radiotherapy in patients with DLBCL

Background and purpose While Chimeric antigen receptor (CAR) T-cell therapy has transformed treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL), over half of patients relapse within 1 year with poor prognosis. Salvage radiotherapy (sRT) achieves high local response rates, but which subgroups benefit...

Jia-Qi Fan, N. Kutsch, J. Heger et al. · 0 citations
Open access Aug 2026

A case of Bundibugyo virus disease treated with monoclonal antibodies and remdesivir.

Clinical data on Bundibugyo virus (BDBV) infection are limited, and no approved virus-specific treatment exists. We describe the case of a previously healthy 39-year-old healthcare worker who acquired BDBV infection while working in Ituri Province, Democratic Republic of the Congo (DRC), and was medically evacuated to...

Alexander Uhrig, Frieder Pfäfflin, P. Tober-Lau et al. · 1 citation
Open access Sep 2026

Durable suppression of viremia by lipid nanoparticle-formulated RNA encoding for a highly potent HIV-1 neutralizing antibody

RNA-LNP-mediated 1-18-LS RibobNAb monotherapy of viremic HIV-1YU2-infected humanized mice resulted in durable HIV-1 suppression without emerging viral escape, a proof-of-principle for effective RNA-mediated bNAb immunotherapy of HIV-1 infection.

Sophie Sayettat, F. Tolksdorf, Robin Johannson et al. · 0 citations

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