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Open access Aug 2026

Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer

The incidence of colorectal cancer (CRC) has risen in recent decades, with a disproportionate increase observed among younger individuals in Japan and other countries. The etiological contribution of the gut microbiota to CRC pathogenesis is recognized, yet the mechanisms involved remain to be fully clarified. Here we...

Satoshi Shiba, Shinichi Yachida, Sayaka Mizutani et al. · 2 citations
Case report Open access Sep 2026

Dedifferentiated Gastric Gastrointestinal Stromal Tumor with Rapid Growth Mimicking Other Malignancies: A Case Report

ABSTRACT INTRODUCTION Gastrointestinal stromal tumors (GISTs) are diagnosed based on morphological and immunohistochemical findings. However, in rare instances, GISTs may undergo morphological and immunophenotypic dedifferentiation, making diagnosis challenging. Here, we report a rare case of a rapidly growing gastric...

Kenji Iijima, Tsuyoshi Takahashi, Y. Kurokawa et al. · 0 citations
Sep 2026

Long-term nutritional outcomes after esophagectomy following induction chemotherapy versus chemoradiotherapy for T4b esophageal cancer.

Esophagectomy following induction chemoradiotherapy was associated with greater long-term weight loss and impaired nutritional recovery compared with surgery following chemotherapy alone, and these findings highlight the need for intensified nutritional surveillance and intervention in patients treated with preoperativ...

K. Sugimura, Koji Tanaka, T. Sugase et al. · 0 citations

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