Author

H. D. de Vries

2 papers indexed here

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Open access Sep 2026

A human iPSC-based perfusable and membrane-free neurovascular unit-on-chip connecting brain organoids to the blood–brain barrier

The blood–brain barrier (BBB) protects the central nervous system by restricting entry of harmful blood-borne factors, but this selectivity actively limits delivery of therapeutics to the brain. Because BBB function is shaped by dynamic interactions within the neurovascular unit (NVU), particularly between brain endoth...

Henrique Nogueira Pinto, Lois Kistemaker, Mikhail Ponomarenko et al. · Lab on a Chip · 0 citations

Open access Aug 2026

Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation

In vivo FLAP antagonism ameliorates disease severity and spinal cord inflammatory gene expression in the experimental autoimmune encephalomyelitis model, an animal model of MS, in both a prophylactic and therapeutic settings.

J. Konings, Fleur Mingneau, Serhii Chornyi et al. · Acta Neuropathologica · 0 citations