The conceptual advances that have reshaped cancer research — from somatic mosaicism, functional genomics and cancer stem cells to tumour metabolism, precision oncology and artificial intelligence — and consider which ideas transformed the field, which fell short of expectations, and what challenges remain.
A. Balmain, René Bernards, H. Clevers et al.· Nature Reviews. Cancer· 0 citations
These findings uncover CAF–bone-marrow cross-talk as a therapeutic target linking stromal inflammation, immune remodeling, and metastatic progression as a therapeutic target linking stromal inflammation, immune remodeling, and metastatic progression.
Yasuto Takeuchi, Hua-Zi Zhang, T. Murayama et al.· bioRxiv· 0 citations
SCISSOR (Single-Cell Inference of Structural States of Ribosomes), a strategy that infers global translation activity in individual cells from the differential protection of ribosomal RNA against nuclease digestion, is introduced, establishing a framework for studying global translation control at single-cell resolutio...
Euan Joly-Smith, Michael VanInsberghe, Kseniia Sarieva et al.· bioRxiv· 0 citations
A large-scale international programme—the Human Cancer Models Initiative—is presented, which involved the generation of a resource of 665 next-generation models from 2,780 donors with 25 cancer types and integrated tumour–model whole genome, exome, methylome and transcriptome analyses.
Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al.· Nature· 7 citations
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