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Divergent roles of interleukin-12p40 and interleukin-18 in severe fibrosing chronic graft-versus-host-disease, immunity, and post-transplant outcomes.
Among 14 cytokines, IL-12p40 and IL-18 emerged as divergent signatures, both were elevated in patients who later developed severe fibrosing cGvHD, but their clinical associations differed markedly.
Development of an investigational medicinal stem cell gene therapy product to attempt curing human immunodeficiency virus infection
This work proposes to test an alternative strategy, namely expression of a designer recombinase which specifically excises HIV provirus from the genome under a Tat-inducible promoter so that expression is restricted to infected cells.