Cross-modality network phenotyping: a multivariate MRI biomarker signature predicts spatial pathology and clinical severity in EAE
Introduction Evaluating novel therapies for multiple sclerosis requires robust, non-invasive biomarkers. In the experimental autoimmune encephalomyelitis (EAE) model, standard disease evaluations rely heavily on subjective clinical motor scoring and terminal histology, which frequently suffer from a mathematical diluti...