Injectable Trimethyl Chitosan Hydrogel with Capsaicin Mitigates Functional Pain and Angio-Osteogenic Coupling in an Animal Model of Osteoarthritis
Osteoarthritis (OA) remains a leading cause of disability worldwide, with current therapies limited to symptomatic relief. In this study, we developed and evaluated a thermoresponsive hydrogel system based on N,N,N-trimethyl chitosan (TMC) for the sustained intra-articular delivery of capsaicin, an established analgesi...