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Author

H. Al-Ameer

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Review Aug 2026

Circular Logic: Engineering Next-Generation Circular RNA Therapeutics for Precision Oncology.

This review argues that circular topology should be viewed as an active pharmacologic variable, not merely a stability enhancement, and dissect recent advances in cap-independent translation initiation, including IRES elements and m6A-driven mechanisms, rolling-circle translation for multi-epitope vaccine design, and programmable stability circuits that integrate tumor-microenvironment cues such as miRNA signatures.

Amr A. El-Sehrawy, H. Al-Ameer, J. Rizaev et al. · 0 citations

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