De novo-designed enzymes have recently achieved high catalytic activity and stereoselectivity while demonstrating exceptional thermostability in entirely novel protein scaffolds. Among these, α-helical barrel protein scaffolds are attractive structures for biocatalysis due to their structural simplicity, high thermosta...
Wael Elaily, Markus Braun, David Stoll et al.· bioRxiv· 0 citations
Over the last decades, transformative catalytic strategies have emerged, with biocatalysis currently exerting a substantial influence on the pharmaceutical and fine chemical sectors. Fast progress in the design of efficient enzymatic processes, however, suffers from the lack of readily available, stable, and customizab...
Wael Elaily, David Stoll, Morakot Chakatok et al.· bioRxiv· 3 citations
Given the involvement of S-layers in host interactions, immune evasion, and pathogenicity, particularly in Bacillusanthracis and Bacillus cereus group species, the identified intermolecular interfaces represent attractive targets for the development of novel antibacterial strategies.
Christoph Grininger, L. Gambelli, Anđela Ðordić et al.· Journal of Biological Chemis...· 0 citations
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