Through genome mining and metabolomic analysis of the mutant strain CRM005, combined with feature-based molecular networking (FBMN) deduplication, five novel natural cyanogrisides (1–5) were selectively isolated and characterized, alongside six previously reported analogs (6–11). Antiproliferative assays demonstrated...
Three pairs of new furo[3,2-c]pyridone derivative racemates, named (±)-phaeopyridones A–C (1–3), together with two new compounds, berkeleyamide E (4), and phaeopyranone (5), were isolated from the endophytic fungus Phaeobotryon negundinis 12020, along with three known compounds, (8S,9S)-dihydroisoflavipucine (6), (8S,9...
Ke Ye, Jie Shi, Hui-Min Wu et al.· Natural Products and Biopros...· 0 citations
These findings expand the structural diversity of decalin polyketides and provide the first evidence of antitubercular activity by this compound family.
Junjie Yu, Shangqian Ning, Yuchang Di et al.· Antibiotics· 0 citations
TRACER (terpene rearrangement annotation via co-attentive enzyme-product representation), a multimodal framework mapping the latent associations between sequence-derived enzyme representations and product chemotypes, establishes a predictive paradigm for the rational discovery and mechanistic elucidation of complex ter...
