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Author

Guojing Tao

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Aug 2026

Drug repurposing-guided discovery of novel methyl quinoline-6-carboxylate RIPK3 inhibitors through structural optimization of Gefitinib.

Overall, this study identifies Gefitinib as a novel RIPK3-targeting scaffold and demonstrates that structure-guided optimization of an EGFR inhibitor can yield potent and selective RIPK3-directed anti-necroptotic agents.

Ying Shi, Guojing Tao, Rui-Xia Zhang et al. · 0 citations

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