Author

Guo-Yuan Wen

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Open access Sep 2026

A recombinant Newcastle disease virus-vectored multi-epitope vaccine confers protection against QX-like infectious bronchitis virus in chickens

Protection was accompanied by an increased frequency of splenic CD3 + CD8 + T cells, particularly after booster immunization, suggesting a role for cellular immunity alongside neutralizing antibodies.

Fei Wang, Jia-Nan Xie, Guo-Yuan Wen et al. · Frontiers in Immunology · 0 citations

Aug 2026

A novel TK/gE-deleted pseudorabies virus vaccine expressing CCL3L1 enhances humoral immunity by stimulating the dendritic cell-T follicular helper-germinal center axis.

Results demonstrate that CCL3L1 acts as an effective molecular adjuvant by potentiating humoral immunity through activation of the conventional DC-T follicular helper cell-GC B cell axis, supporting HNX-ΔTK/ΔgE-CCL3L1 as a potential vaccine for the control of emerging PRV variants.

Lun Yao, Si-Wen Hao, Chengjun Zhang et al. · Veterinary Microbiology · 0 citations