Guo-Shun Luo

Lysine-targeted covalent inhibitors: mechanistic advances, pharmacological perspectives and translational challenges.

Targeted covalent inhibitors can provide potent and durable target modulation, but their development has largely centered on cysteine. Lysine offers a complementary covalent handle because it is widely distributed across catalytic sites, ligand-binding pockets, allosteric regions, and protein-protein interaction interf...