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Guo-Jun Chen

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Review Open access Sep 2026

The HCMV terminase as an antiviral target: structural insights, inhibitory mechanisms, and the era of letermovir

Current understanding of the interaction between letermovir and the HCMV terminase is summarized, focusing on structural organization, inhibitory mechanisms, resistance mutations, and emerging approaches for next-generation inhibitor development, and highlighting key unresolved questions that will guide future structur...

Guo-Jun Chen, Yu-Qi Li, Jin-Rui Chen et al. · 0 citations

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