Open access
Sep 2026
Sestrin2 mitigates obesity-associated HFpEF via adaptive IRE1α-XBP1 signaling and redox regulation.
It is demonstrated that Sestrin2 has cardioprotective effects on obesity-associated HFpEF and is associated with the activation of adaptive IRE1α-XBP1 signaling involving Sigmar1, together with improved metabolic and redox homeostasis.
Ke-Xin Zhang, Cheng-Xia Kan, Jing-Wen Zhang et al.
· Acta Biochimica et Biophysic... · 0 citations