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Guo-Ji Xiong

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Open access Sep 2026

Sestrin2 mitigates obesity-associated HFpEF via adaptive IRE1α-XBP1 signaling and redox regulation.

It is demonstrated that Sestrin2 has cardioprotective effects on obesity-associated HFpEF and is associated with the activation of adaptive IRE1α-XBP1 signaling involving Sigmar1, together with improved metabolic and redox homeostasis.

Ke-Xin Zhang, Cheng-Xia Kan, Jing-Wen Zhang et al. · 0 citations

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