While dietary therapies targeting individual amino acids in cancer show promise in modulating tumor metabolism, the issue of nutrient competition between tumors and the immune system remains unresolved. The current approaches face significant challenges, particularly in the context of metabolic adaptability and immune...
Ben-Chi Zhao, Xin-Yuan Zhao, Wen-Xiu Li et al.· Molecular Biomedicine· 0 citations
Programmed cell death protein 1/programmed death ligand 1 (PD-1/PD-L1) blockade can produce durable responses, but primary and acquired resistance are common. Treatment outcome is influenced by antigen presentation, T-cell localization, suppressive myeloid populations, metabolic stress, and the gut microbiome, all of w...
Hui-Ya Cheng, Mei-Lun Chen, Min Xiao et al.· Biomedicines· 0 citations
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