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Review Open access Sep 2026

Dysfunction of CD58 in tumor immune evasion: from mechanistic regulation to therapeutic resistance

CD58, the primary ligand of the co-stimulatory receptor CD2, plays a crucial role in the formation of the immunological synapse (IS) and the initiation of antitumor immunity involving T cells and natural killer (NK) cells. Aberrant CD58 expression, resulting from genomic inactivation, epigenetic silencing, transcript...

Peng-Fei Guo, Ming Yi, Yu-Jie Gan et al. · 0 citations
Review Aug 2026

Noninvasive Characterization of Tumor Heterogeneity in Locally Advanced Nasopharyngeal Carcinoma: From Progression-Free Survival Prediction to Biological Correlates.

BACKGROUND Locally advanced nasopharyngeal carcinoma (LA-NPC) shows substantial variability in progression-free survival (PFS) despite radiotherapy-based treatment. Clinical factors and conventional radiomics may not adequately characterize the spatial organization of intratumoral heterogeneity. Whether topology-aware...

Wei Li, Ming Yi, Guo Chen et al. · 0 citations

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