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Guido Narduzzi

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Open access Sep 2026

Weak interactions drive selective proteome demixing and tune the differential response to environmental perturbations

QuPID-MS, which measures the propensity of proteins to phase separate in native cell extracts proteome-wide, finds that weak interactions drive condensation of half of the proteome in a crowding- and temperature-dependent manner and presents evidence that this proteome demixing occurs in cells.

Guido Narduzzi, Federico Zucca, Leo Willig et al. · 0 citations

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