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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Guanjie Shang

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Jul 2026

IQGAP2 regulates phagocytic-like activity and PD-L1 expression in glioma through the JAK2/STAT3 axis

These findings characterize IQGAP2 as a novel regulator orchestrating tumor-intrinsic phagocytic-like programs and immune checkpoint modulation, suggesting that targeting the IQGAP2/JAK2/STAT3 axis represents a potential therapeutic strategy to overcome immune evasion in glioma.

Yuduo Guo, Guanjie Shang, Chao Zhao et al. · 0 citations

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