Author

Guanghao Hu

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Open access Aug 2026

Disulfide-crosslinked triblock polyampholyte vesicles as a reducible platform for polyplex-based nucleic acid delivery.

Polyion complex (PIC) vesicles are attractive carriers for mRNA delivery, yet their assembly is often compromised by charged cargos that disrupt the electrostatic interactions required for vesicle formation. Here, we report triblock polyampholyte vesicles (TBPVs) that encode preferential polymer-polymer interactions, e...

Guanghao Hu, Takayoshi Watanabe, Pengwen Chen et al. · Colloids and Surfaces B: Bio... · 0 citations

Aug 2026

Polycation chain length determines the in vivo mRNA delivery efficiency of block copolymer micelles.

Tuning polycation chain length with core π-π interactions is key to unlocking highly efficient mRNA delivery in micelles, and achieves 2-fold higher protein expression in vivo compared to shorter or longer chain variants.

Yuki Nakashima, Pengwen Chen, Guanghao Hu et al. · Biomaterials Science · 0 citations