Beyond static uptake: rethinking [18F]FMISO PET for quantifying and interpreting tumor hypoxia
Abstract Background Tumor hypoxia is a critical microenvironmental determinant of progression, treatment resistance, and prognosis in solid tumors. Among hypoxia-targeted imaging approaches, [ 18 F]fluoromisonidazole ([ 18 F]FMISO) positron emission tomography (PET) provides a noninvasive imaging readout related to the...