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Author

Guangzheng Wei

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Oct 2026

A Radical Addition–Diradical Coupling Switch Unifies Cytochrome P450-Catalyzed Diketopiperazine Dimerization

Cytochrome P450 dimerases generate the remarkable structural diversity of dimeric diketopiperazine (DKP) natural products through highly selective intermolecular radical-mediated reactions. Although radical addition mechanisms have been established for most bacterial DKP dimerization modes, the molecular basis underl...

Ye-Qing Du, Tai-Ping Zhou, Wen-Ya Tian et al. · 0 citations
Open access Sep 2026

Structural and Mechanistic Basis of Dual Substrate Promiscuity in the Acyltransferase AntB Enables Late-Stage Diversification of Natural Products.

This study systematically characterize AntB and uncover its remarkable dual substrate promiscuity, and establishes AntB as a versatile biocatalyst for late-stage natural product diversification.

Meng-Meng Zheng, Yu-Han Dai, Xiang-Yu Li et al. · 0 citations
Aug 2026

Iterative Enoyl Reduction by a FabV-Family Enzyme Expands the Chemical Landscape of Discrete Polyketide Synthases.

PbrC16, a FabV-family ER from a manumycin-type biosynthetic gene cluster (BGC) in Peterkaempfera bronchialis is characterized and reveals the molecular basis for its exceptional substrate promiscuity and versatile acyl carrier protein (ACP) recognition.

Yan Gao, Kai Jiang, Yu-Han Dai et al. · 0 citations

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