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Author

Guangjie Liang

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3 papers indexed here

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Aug 2026

Synthetic Carbon-Efficient Pathway and Programmable Microenvironment for Sustainable Caffeic Acid Production

Microbial production of phenolic acids offers a sustainable alternative to plant extraction, reducing carbon loss and environmental impact. Here, we present a multi-level engineering strategy in Escherichia coli integrating carbon-efficient pathways, enzyme optimization, and subcellular compartmentalization. A synthe...

Binbing Xu, Qin-Yu Guo, Qi Cui et al. · 0 citations
Open access Sep 2026

Reprogramming energy system for growth and bioproduction from CO₂ and methanol in Escherichia coli

Microbial CO₂ assimilation provides a strategy for sustainable biomanufacturing. However, CO₂ reduction requires substantial energy input, while native energy systems are tightly regulated and extensively consumed by endogenous metabolism, limiting assimilation efficiency. Here, we design and construct an orthogonal en...

Kai-Fang Liu, Cong Gao, Guang-Jie Liang et al. · 0 citations
Jul 2026

Metabolic flux reprogramming and protein engineering drive efficient l-arginine biosynthesis.

An enzyme-constrained model was used to identify 11 gene targets affecting l-arginine production and engineered the rate-limiting enzyme argininosuccinate synthetase to construct the strain Arg11, achieving the best performance reported to date.

Shengyang He, Qi Sheng, Gang Men et al. · 0 citations

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