Guan-Nan Jiang

Cytotoxic lymphocyte death drives monocyte activation and TNF/IFN-γ synergism in TBK1 deficiency

TBK1 deficiency drives the pathogenesis of inborn errors of cell death (IECDs). However, the underlying cellular mechanisms remain unclear. Here, we identified a novel homozygous loss-of-function TBK1 variant resulting in exon 18 deletion (p.R621Sfs*21) that led to loss of TBK1 expression in a patient with system...