Acute liver injury (ALI) is a life-threatening clinical condition with limited therapeutic options. Through network pharmacology screening, we identified oxysophocarpine (OSC), a natural compound derived from traditional Chinese medicine, as a potent reactive oxygen species-scavenging agent. In LPS/D-GalN-induced ALI m...
Jin-Jin Shi, Yan-Jun Liu, Ran Wang et al.· Free Radical Biology & Medic...· 0 citations
Cadmium (Cd) is a ubiquitous environmental pollutant with an exceptionally long biological half-life (10–30 years) and high multi-organ toxicity. While chronic cadmium exposure has been extensively studied, the pathological mechanisms and prophylactic strategies for acute cadmium poisoning remain poorly defined. Here,...
Jing Yu, Feng Xu, Ran Wang et al.· Antioxidants· 0 citations
Mechanistically, ZNF207 contributes to tumour development and progression through modulation of major oncogenic signalling pathways, including phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin signalling, nuclear factor erythroid 2-related factor 2 (NRF2)-related ferroptosis, spindle checkpoint...