Persistent IL-18 fuels expansion of CD38+HLA-DR+CD8+ T cells in Still's disease and macrophage activation syndrome.
OBJECTIVE Still's disease (SD) is an autoinflammatory disorder characterized by remarkably high IL-18 levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is asso...