Author

Gregory W. Thomas

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Open access Oct 2026

Decanoic acid additively suppresses IL-1β and enables pharmacologic dexamethasone dose-sparing in LPS/ATP-stimulated THP-1 macrophages

Systemic inflammatory response syndrome, driven by trauma or infection, involves excessive innate immune activation. Dexamethasone (DEX), a synthetic glucocorticoid, suppresses inflammation, although adverse side effects limit its clinical use. The inflammasome, a multiprotein complex that assembles in response to infl...

Melissa A. Hausburg, K. Banton, Christopher D. Cassidy et al. · PLoS ONE · 0 citations

Open access Oct 2026

Decanoic acid reduces extracellular prostaglandin accumulation, inhibits MRP4 transport, and enhances low-dose dexamethasone effects in IL-1β-stimulated human osteoarthritis synoviocytes

Objective Persistent extracellular prostaglandin signaling contributes to synovial inflammation and pain in osteoarthritis (OA), although prostaglandin E2 (PGE2) can also have context-dependent homeostatic functions. Decanoic acid (DA) is a 10-carbon medium-chain fatty acid with reported peroxisome proliferator-activat...

Jason S. Williams, Melissa A. Hausburg, Gregory W. Thomas et al. · Frontiers in Medicine · 0 citations

Open access Sep 2026

Complementary Regulation of Inflammatory, Catabolic, and PPARγ Signaling by Dexamethasone and Decanoic Acid in Donor-Specific Human Chondrocyte Models

Background/Objectives: This study examined whether dexamethasone (Dex) and decanoic acid (DA) exert complementary effects on inflammatory signaling, catabolic gene expression, and peroxisome proliferator-activated receptor gamma (PPARγ) activation in human chondrocytes. Methods: Two donor-specific primary human chondro...

Gregory W. Thomas, Jason S. Williams, R. Bar-Or et al. · Biomedicines · 1 citation