Review
Open access
Jul 2026
A new conceptual framework for PKD1 in ADPKD; integrating DNA structures and inflammation.
This synthesis supports a conceptual model in which intrinsic sequence-dependent mutational susceptibility at the human PKD1 locus may interact with localized inflammatory microenvironments characterized by oxidative stress and epithelial proliferation to contribute to recurrent somatic second-hit formation.
L. Hanakahi, Tara Subrahmanyan, Gregory B. Vanden Heuvel et al.
· BMC Nephrology · 0 citations