In this large multicenter sample, PSP pathology was more common than other FTLD-Tau subtypes, and incident PSP often differed clinically from “classic” PSP, and PSP tau pathology was more severe overall in prevalent PSP.
Benjamin J. Cushing, Ryan K. Shahidehpour, E. Abner et al.· Acta Neuropathologica· 0 citations
Background. Alzheimer's disease (AD) pathology often accumulates years before memory loss, creating a need to identify high-risk individuals presymptomatically. Polygenic risk scores (PRS) stratify AD risk, but individual-level predictions remain uncertain. Extreme PRS may identify high-risk individuals independent of...
Elizabeth L. Ward, Peter T. Nelson, Y. Katsumata et al.· medRxiv· 0 citations
Introduction: Polygenic risk scores (PRS) may improve Alzheimer's disease (AD) risk prediction before symptom onset, yet choosing an appropriate model can be challenging. Methods: Using the standardized GenoPred pipeline, 1,752 PRS models (9 algorithms; 584 configurations; 3 genome-wide association studies) were evalua...
Elizabeth L. Ward, Peter T. Nelson, Y. Katsumata et al.· medRxiv· 0 citations
A pathobiological definition of disease is proposed to provide a road map for developing biomarkers that accurately reflect the underlying pathobiology of disease and for advancing therapeutic candidates that effectively target fundamental disease mechanisms.
M. Benatar, SJ Barmada, Gregory A. Jicha et al.· JAMA Neurology· 1 citation
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