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Grant Goldman

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Open access Aug 2026

Efficient exploration of sequence space enables rapid generation of functional genome editors

An approach to create novel, functional proteins through the integration of deep mutational scanning, structural analysis, and evolutionary mining within prompts for a generative protein language model (PLM) is described and the utility of this approach is demonstrated with the generation of novel compact RNA-guided nucleases.

Nicholas W. Hughes, Sourab Kulkarni, Grant Goldman et al. · 0 citations

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