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Author

Gracia M. Bonilla

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Open access Aug 2026

A multi-functional oral small molecule targeting energy and lipid metabolism to treat obesity and related metabolic disorders

Obesity and related metabolic disorders have surged globally, and are mechanistically interconnected through dysregulated energy and lipid metabolism pathways. Current incretin-based obesity treatments act to decrease food intake, but are associated with gastrointestinal side effects and muscle wasting. Here, we identi...

Justin Y. Lee, Chi Zhu, Melissa A. Boldridge et al. · 1 citation
Open access Sep 2026

A positively selected microRNA controls a reversible aging program in striated muscle

It is shown that antisense oligonucleotide-mediated inhibition of miR-128-3p restores muscle mass and function in aged mice, improves cardiac function while limiting adverse remodeling following myocardial infarction, and ameliorates skeletal and cardiac muscle pathology in mouse and pig models of Duchenne muscular dys...

Melissa A. Boldridge, Lei Xu, Xiao-Yin Wang et al. · 0 citations

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