Exploring Anti-Breast Cancer Potential and Mechanism of Novel Xanthohumol-Metformin Conjugate by Integrating Network Pharmacology, Molecular Docking and Simulation Approaches
Natural product scaffolds can be combined with repurposed drugs, so called conjugate molecules may exhibit improved pharmacology. We designed a conjugate (XN-MT) of xanthohumol (a prenylated chalcone with anticancer properties) and metformin (an antidiabetic drug with reported anticancer effects) and evaluated its pote...