Open access
Aug 2026
Loss of cGAS alters microglial homeostasis, promotes progressive neurodegeneration, and impairs neuroimmune coordination
The early physiological decline of cGAS in brain immune populations, combined with the broad neuroimmune dysfunction observed in cGASKO mice, raises the possibility that this early window of cGAS expression may contribute to the brain's capacity to sustain immune surveillance and resist age-related neurodegeneration.
Paola Murgas, S. Mesa, Marcela Escandón et al.
· Biological Research · 0 citations