Aug 2026
The DreAM-plus integrative RNA switch enhances transient AAV expression and reduces side effects of gene editing.
DreAM-plus, a multilayer RNA switch that integrates an aptamer-based polyA regulator (pA), a drug-elicitable alternative splicing module (DreAM) and an engineered P2A element with conditional upstream open reading frames (uORFs), achieves transient expression of an array of gene editors with a temporal resolution less...
Yue-Yang Zhang, Yuhan Yang, Zhanzhao Liu et al.
· Molecular Therapy · 0 citations