Gong-Yi Zhang

DSIF, NELF, the Integrator complex, and the promoter-proximal RNA Polymerase II pausing are coupled in metazoans.

Both DSIF (Spt4/5) and the negative elongation factor, NELF, were assigned as two initiators of promoter-proximal RNA Polymerase II (Pol II) pausing in metazoans. Similarly, the Integrator complex is assigned to terminate Pol II pausing and subsequently trigger the release of paused Pol II. Furthermore, the working mec...