The cellular form of the prion protein (PrPC) is known for its involvement in the pathogenesis of prion diseases. Recent research implicates the physiological isoform of PrP in neuronal development, excitability, and synaptic plasticity, as well as in other biological processes. However, its precise function in the dev...
Anna Burato, Alessio Di Clemente, Camilla Lodetti et al.· bioRxiv· 1 citation
Synucleinopathies are a group of neurodegenerative disorders characterized by the misfolding, aggregation, and accumulation of α-synuclein (α-syn) into oligomeric assemblies and amyloid inclusions. Alongside neurons, glial cells can internalize pathological α-syn and play a major role in its degradation. Despite...
Lea Šustić, Elena de Cecco, Sandesh Neupane et al.· Cell Communication and Signa...· 0 citations
We describe a patient carrying the GRN p.Thr272Serfs*10 mutation, who presented with parkinsonism at onset and later developed prodromal frontotemporal dementia, in whom seed amplification assay on olfactory mucosa and skin analyses suggest mixed TDP-43 and α-synuclein co-pathology, highlighting how combining these tec...
P. Caroppo, V. Aprea, C. Villa et al.· Molecular Neurodegeneration· 0 citations
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