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Author

Giuliana P. Mognol

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Open access Sep 2026

15 Defining Systemic and Tumor-Intrinsic Biomarkers of Immune Suppression in Renal Cell Carcinoma

Abstract Background Renal cell carcinoma (RCC) is characterized by a highly immunosuppressive tumor microenvironment enriched in tumor-associated macrophages (TAMs) and regulatory T cells (Tregs), both of which correlate with poor clinical outcomes. TAMs in RCC commonly exhibit an immunosuppressive phenotype, marked by...

Giuliana P. Mognol, E. Wang, William Harris et al. · 0 citations
Open access Jul 2026

An IL-34–IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression

It is shown that KRASG12D mutations in lung epithelium drive proliferation of resident, embryonically-derived alveolar macrophages, which then promote tumor cell proliferation and protection from ferroptosis, leading to tumor progression.

Jaroslav Zak, Hui Chen, Erpei Wang et al. · 0 citations

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