Open access
Aug 2026
Temporal uncoupling of radial glia lineage progression in cortical organoids.
Radial glial progenitors (RGPs) produce all excitatory neurons in the developing cerebral cortex. Mosaic analysis with double markers (MADM)-based lineage tracing in vivo has revealed a quantitative framework of RGP lineage progression1. Here we established MADM technology2,3 in mouse embryonic stem cells to probe RGP...
Melissa Stouffer, Osvaldo A. Miranda, F. Pauler et al.
· Nature · 2 citations