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Author

Giovanni Restuccia

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Open access Oct 2026

Characterizing single-shell NODDI-DTI estimates through associations with plasma biomarkers and cognitive performance

White matter (WM) degeneration is an important feature of aging and Alzheimer’s disease (AD). Neurite orientation dispersion and density imaging derived from diffusion tensor imaging (NODDI-DTI) is a technique that allows the estimation of neurite density index (NDI) and orientation dispersion index (ODI) in WM fro...

Giovanni Restuccia, A. Ielo, V. L. Buono et al. · 0 citations
Open access Sep 2026

A Machine Learning Framework for Binary and Multiclass Classification of Cognitive Impairment Using Structural MRI Biomarkers

The findings support the potential role of structural MRI biomarkers combined with interpretable ML approaches for the classification of cognitive impairment and the integration of demographic variables improved model performance, particularly in binary discrimination tasks, whereas multiclass classification remained m...

Alessia Venuto, Ambra Faraci, Alessandro Grimaldi et al. · 0 citations

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