Review
Open access
Sep 2026
Clinical Implications of the Type and Genomic Location of Pathogenic BRCA1 and BRCA2 Variants in Hereditary Breast and Ovarian Cancer.
Germline pathogenic or likely pathogenic variants (P/LPVs) in BRCA1 and BRCA2 are major determinants of hereditary breast and ovarian cancer susceptibility. Although clinical management has traditionally relied on the presence of a BRCA1/BRCA2 alteration regardless of its specific characteristics, growing evidence sugg...
Emma Zattarin, C. Piombino, E. Tenedini et al.
· Critical reviews in oncology... · 0 citations