Open access
Sep 2026
Mechano-sensing channels PIEZO1 and PIEZO2 regulate mitral valve serotonin-mediated homeostasis and pathophysiology.
A novel link between mechano-transduction, 5-HT production and receptor signaling, and collagen synthesis is identified, suggesting PIEZO1, PIEZO2, and downstream 5-HT pathways as potential therapeutic targets for mitigating MR progression.
Stanley J. Stachelek, Emily J. Hauber, Xiao-Qiu Yang et al.
· Cardiovascular Research · 0 citations