Giovanna Cazzolla

Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy-NPY axis.

It is shown that autophagy in these neurons non-cell autonomously controls hippocampal presynaptic active zone architecture and proteostasis, while maintaining NPY peptide levels, revealing a pathway by which hypothalamic autophagy and NPY signaling regulate hippocampal synaptic architecture, linking metabolic state to...