Giorgia Zanetti

Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo 2332710

While allogeneic grafts undergo strong immune infiltration and tissue remodeling, autologous stem cell-derived islet grafts remain largely protected, even in the presence of autoreactive T cells, indicating that additional stimuli may be required to trigger autoimmune β-cell targeting in vivo.