Ghazal Esfahani Maragheh

Multicellular human cardiac organoids with real-time calcium imaging enable functional modeling of heart failure and myocardial infarction.

Cardiovascular diseases remain leading causes of mortality, yet progress in therapy development is limited by inadequate human-relevant models. Here, we develop a simplified, multicellular human iPSC-derived cardiac organoid system that enables functional and translational disease modeling. Using a streamlined two-comp...