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Ghalbaa N. Alshahrani

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Open access Aug 2026

Coumarin-based dual kinase inhibitors targeting CDK6 and VEGFR-2: experimental and computational validation

Mechanistic studies revealed that compound 7e induced significant apoptosis, promoted S-phase cell cycle arrest, and effectively inhibited cell migration in HCT-116 cells, identifying him as a promising dual VEGFR-2/CDK6 inhibitor with potent and selective anticancer activity.

Hazem Elkady, Walid E. Elgammal, I. Eissa et al. · RSC Advances · 0 citations