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Author

George M. Church

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Review Jul 2026

Large-scale genome structure interrogation via recombinase-mediated rearrangements of multiplexed prime edits in repetitive elements.

This Protocol leverages prime editing to insert recombinase recognition sites into repetitive genomic regions, such as LINE-1 elements, thereby enabling extensive genetic modifications in human cells, and supports a wide range of studies, including genome-wide functional analyses and essentiality mapping.

Lisa M. Riedmayr, Jonas Koeppel, George M. Church et al. · 0 citations

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