The standard genetic code uses 64 codons to encode 20 canonical amino acids across domains of life. New-to-nature genetic codes enable new chemistries, therapeutics and ecosystem engineering, but recoding the genome of an organism is exceptionally challenging1, 2, 3, 4, 5–6. Here we describe automated genetic tRNA expa...
Felix Radford, Nayan Sapers, Hana M. Burgess et al.· Nature· 0 citations
A multiplex genome engineering pipeline capable of introducing up to eleven genomic modifications across seven different genes simultaneously in viable founder mice is established, advancing methods of rapid establishment of complex genetic models, with a wide array of applications.
Rui Chen, M. Coquelin, Kanokwan Srirattana et al.· Cell Reports Methods· 0 citations
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